Fmoc-Tyrosine Derivative

Bachem are now offering a new Fmoc-tyrosine derivative. This has recently been developed by Undén’s group and is used for solubilisation of hydrophobic peptides. Poor solubility of synthetic peptides is seen as a major problem in solid phase peptide synthesis. However the following method can reduce such problems for peptides with tyrosine residues.

The lateral Boc group of Tyr(Boc-Nmec) is removed during the cleavage from the resin leaving a protonated N-methylethylamino moiety which increases the aqueous solubility of the crude peptide and thus facilitates its purification. The solubilising Nmec group is split off via an intramolecular cyclization in neutral or slightly basic solution.

Please refer to our online catalogue which now includes Fmoc-Tyr(Boc-Nmec)-OH or please contact us directly for more information on the Fmoc-tyrosine derivative.